LS-LT combo engine question

[Vimes]

Has anyone used a Chevy LT block for an LS build? Asking because the LT block is aluminum and supposed to be able to handle 900+HP from the factory before you must be concerned with it. The most I'm interested in is 600-700 crank HP as I just want a fun to drive truck and not something I have to fight with to drive. I know the heads have a different dowel location but beyond that, anything to stop one from using an LT block and rotating assembly with LS heads and ECM? Not interested in an LT topside due to the intake valve carbon fouling problem.